Email Alert   |   RSS

Journal of Integrative Nursing ›› 2019, Vol. 1 ›› Issue (1): 59-66.doi: 10.35437/intnur.issn.2663-4481.2019.01.01.08

Previous Articles     Next Articles

Risk and Cumulative Risk of Acute Ischemic Stroke Recurrence in China: A Systematic Review and Meta-Analysis

You-Hua LIU1, Hong GUO*,1, Gui-Ying LIU2, Luo YANG1, Hai-Yan WANG1, Dan ZHAO1, Hui JU1, Shao-Hua GONG1, Xiao-Ping YI1   

  1. 1School of Nursing, Beijing University of Chinese Medicine, Beijing 102448, China;  2Department of Brain Surgery, Oriental Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
  • Received:2019-04-08 Revised:2019-04-15 Accepted:2019-04-20 Online:2019-04-16 Published:2019-05-21
  • Contact: Hong GUO, Associate professor, Clinical Nursing Department, School of Nursing, Beijing University of Chinese Medicine, Beijing 102448, China


Objective: To comprehensively evaluate the risk of recurrence after initial ischemic stroke, and to provide a relatively comprehensive reference for the prevention and control of stroke recurrence.

Methods: CNKI, VIP, Wanfang, PubMed, Web of Science, Embase and other databases were collected to investigate the status of recurrence after initial ischemic stroke, the search period of which was from the establishment of databases to March 2019. And then quality evaluation and data extraction were carried out. The overall cumulative risks of stroke recurrence at 3 months, 6 months, 1 year, 2 years and 5 years after initial ischemic stroke were calculated, and heterogeneity analysis was performed.

Results: A total of 29 studies from 19 provinces (cities, autonomous regions) in China were included. The cumulative total sample size was 22 484 cases, the cumulative recurrent sample size was 3 309 cases. The pooled cumulative risk was 4.5% (95% CI: 3.1-5.8) at 3 months, 7.8% (95% CI: 5.6-10.0) at 6 months, 13.6% (95% CI: 11.0-16.2) at 1 year, 17.5% (95% CI: 12.4-22.6) at 2 years and 30.9% (95% CI: 20.2-41.7) at 5 years after initial ischemic stroke.

Conclusions: The recurrence rate of acute ischemic stroke in China is high. It is recommended that all levels of medical and health departments strengthen the prevention and treatment of ischemic stroke recurrence to reduce the recurrence of ischemic stroke and improve the prognosis of patients.

Key words: Acute ischemic stroke, Recurrence, Meta-analysis, Frequency