Abstract: There are many patients in the blood purification center who need maintenance hemodialysis to maintain life. Those patients generally have low resistance and are easily exposed to coronavirus because they go back and forth the hospital and residence three times a week and closely contact with family, caregivers, community personnel, people in various means of transportation, medical staff, and other patients visiting hospital. Therefore, the blood purification center has become a high-risk environment for the spread of COVID-19 infection. In view of this, our center quickly responded to the formulation and implementation of infection prevention and control measures suitable for the characteristics of the blood purification center and continuous renal replacement therapy (CRRT) emergency plan for fever and suspected patients. According to these measures, we have a positive effect on preventing and controlling nosocomial infection in the blood purification center.

Key words: Blood purification center, COVID-19, infection prevention and control, management, three-level screening